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Hiding in plain sight: HDL dysfunction

Understand components and mechanisms of HDL particles, reverse cholesterol transport,
and how to treat dysfunctional HDL – an overlooked cardiovascular risk.

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The secret life of HDL


A complex protector

For decades we’ve recognized high-density lipoprotein (HDL) as a protector of the cardiovascular system. There’s truth to that concept, but it’s too simplistic.



In the last 20 years a growing body of research in top-tier journals has exposed a hidden truth to HDL particles – HDL dysfunction.


Needs recovery

Below is the story of HDL: how it functions, when it doesn’t, and how you can help your patients recover HDL function.

Learn more about HDL

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HDL particle1
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HDL Storyboard 11_12-2
HDL dysfunction protocol image
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Labs to identify HDL risk

Learn which lab tests can help you better understand HDL and cardiovascular risk.


HDL-C testing


HDL-P testing


HDL mapping


HDL-size and density


Surrogate markers

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Treating HDL dysfunction


Research has shown that eating a Mediterranean diet helps reverse HDL dysfunction.


Research demonstrates making lifestyle changes such as exercise and smoking cessation can reverse HDL dysfunction.

MI_  Targeted Nutrition Bioactives

Targeted nutraceutical ingredients have been shown to support multiple facets of HDL and protect its function.

  • 1 Diet

  • 2 Lifestyle

  • 3 Nutrition supplement

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Metagenics Institute is a trusted, peer-to-peer, evidence-based educational resource for nutrition and personalized medicine. At Metagenics Institute, we translate credible research with scientific integrity into innovative and actionable clinical decision-making. Metagenics Institute supports a diverse practitioner base to optimize patient outcomes by shifting existing paradigms in healthcare. Our mission is to transform healthcare by inspiring and educating practitioners, and their patients, about personalized lifestyle medicine.

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